List Of Psychedelic Drugs

List Of Psychedelic Drugs 1

List Of Psychedelic Drugs 2
List of psychedelic drugs 1

List of psychedelic drugs 2
List of psychedelic drugs – WikiMili, The Best Wikipedia Reader

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The following is a list of psychedelic drugs of various classes, including both naturally occurring and synthetic compounds. Serotonergic psychedelics are usually considered the “classical” psychedelics, whereas the other classes are often seen as having only secondary psychedelic properties; nonetheless all of the compounds listed here are considered psychoactive in humans to some degree.

  • Serotonergic psychedelics (serotonin 5-HT2A receptor agonists)
  • Empathogens/entactogens (serotonin (5-HT) releasing agents)
  • Dissociatives (NMDA receptor antagonists)
  • Cannabinoids (CB-1 cannabinoid receptor ligands)
  • Other
  • See also
  • References

Some of these compounds may be classified differently or under more than one category due to a unique structural classification, multiple mechanisms of action, or the fact that the precise pharmacodynamic actions of the compound are not yet completely understood. Because of the vast amount of possible substitutions and chemical analogs of most psychedelic compounds, the total diversity of chemical compounds which produce psychedelic effects in humans is not fully reflected within this list, leaving room for many that have not yet been sufficiently investigated and others that have not yet been discovered.

Naturally occurring compounds are marked with a †.

  • Indoles
    • Tryptamines (more specifically alkylated tryptamines])
      • Psilocin†, also known as ‘4-HO-DMT’; another active constituent of the Psilocybe genus of mushrooms; also a metabolite of psilocybin and psilacetin
      • Psilocybin†, also known as ‘4-PO-DMT’; the primary active constituent of the Psilocybe genus of mushrooms; its effects are partially attributed to psilocin, to which it is a prodrug via dephosphorylation
      • Bufotenin†, also known as ‘5-HO-DMT’ and dimethylserotonin; another constituent of the skin and venom of psychoactive toads, its psychedelic activity is disputed; also a metabolite of 5-MeO-DMT
      • Baeocystin†, also known as ‘4-PO-NMT’; another active constituent of the Psilocybe genus of mushrooms; its psychedelic activity is disputed
      • Aeruginascin†, also known as ‘4-PO-N-TMT’, an active constituent of the mushroom Inocybe aeruginascens
      • 5-MeO-DMT†, the primary active constituent of the skin and venom of psychoactive toads, a prodrug to bufotenin via demethylation
      • N,N-Dimethyltryptamine†, also known as ‘DMT’; the primary active constituent of the Amerindian brew ayahuasca; endogenously present in various plants and animals, including humans, possibly a trace amine neurotransmitter
      • 5-Bromo-DMT†, was found in the marine invertebrates Smenospongia aurea and Smenospongia echina , as well as in Verongula rigida
      • N-Methyl-N-ethyltryptamine, also known as ‘MET’
      • N-Methyl-N-isopropyltryptamine, also known as ‘MiPT’
      • N-Methyl-N-propyltryptamine, also known as ‘MPT’
      • N,N-Diethyltryptamine, also known as ‘DET’
      • N-Ethyl-N-isopropyltryptamine, also known as ‘EiPT’
      • N-Methyl-N-butyltryptamine, also known as ‘MBT’
      • N-Propyl-N-isopropyltryptamine, also known as ‘PiPT’
      • N,N-Dipropyltryptamine, also known as ‘DPT’
      • N,N-Diisopropyltryptamine, also known as ‘DiPT’
      • N,N-Diallyltryptamine, also known as ‘DALT’
      • N,N-Dibutyltryptamine, also known as ‘DBT’
      • N-Ethyltryptamine, also known as ‘NET’
      • N-Methyltryptamine†, also known as ‘NMT’; its psychedelic activity is disputed
      • Trimethyltryptamine, also known as ‘TMT’ (2,N,N-TMT, 5,N,N-TMT, and 7,N,N-TMT)
      • α-Methyltryptamine, also known as ‘αMT’ and ‘AMT’; also has entactogenic properties
      • α-Ethyltryptamine, also known as ‘αET’ and ‘AET’; also has entactogenic properties
      • α,N-DMT
      • α,N,N-Trimethyltryptamine, also known as ‘α-TMT’
      • Ethocybin, also known as ‘4-PO-DET’, ‘CEY-19’, and ‘CEY-39’
      • 4-HO-MET, also known as ‘Metocin’, ‘Methylcybin’, and ‘Colour’
      • 4-HO-DET, also known as ‘Ethocin’ and ‘CZ-74’
      • 4-HO-MPT, also known as ‘Meprocin’
      • 4-HO-MiPT, also known as ‘Miprocin’
      • 4-HO-MALT
      • 4-HO-DPT, also known as ‘Deprocin’
      • 4-HO-DiPT, also known as ‘Iprocin’
      • 4-HO-DALT, also known as ‘Daltocin’
      • 4-HO-DBT
      • 4-HO-DSBT
      • 4-HO-αMT
      • 4-HO-MPMI, also known as ‘Lucigenol’
      • 4-HO-1,N,N-TMT, also known as ‘1-Me-4-HO-DMT’ and ‘1-methylpsilocin’
      • 4-HO-5-MeO-DMT, also known as ‘Psilomethoxin’
      • 4-AcO-DMT, also known as ‘psiloacetin’; its effects are partially attributed to psilocin, to which it is a prodrug via deacetylation
      • 4-AcO-MET, also known as ‘Metacetin’
      • 4-AcO-MiPT
      • 4-AcO-MALT
      • 4-AcO-DET, also known as ‘Ethacetin’
      • 4-AcO-EiPT, also known as ‘Ethipracetin’
      • 4-AcO-DPT, also known as ‘Depracetin’
      • 4-AcO-DiPT, also known as ‘Ipracetin’
      • 4-AcO-DALT, also known as ‘Daltacetin’
      • 4-MeO-DMT
      • 4-MeO-MiPT
      • 5-MeO-NMT†
      • 5-MeO-MET
      • 5-MeO-MPT
      • 5-MeO-MiPT, also known as ‘Moxy’; also has entactogenic properties
      • 5-MeO-MALT
      • 5-MeO-DET
      • 5-MeO-EiPT
      • 5-MeO-EPT
      • 5-MeO-PiPT
      • 5-MeO-DPT
      • 5-MeO-DiPT, also known as ‘Foxy Methoxy’
      • 5-MeO-DALT
      • 5-MeO-αMT, also has entactogenic properties
      • 5-MeO-αET, also has entactogenic properties
      • 5-MeO-MPMI
      • 5-MeO-2,N,N-TMT , also known as ‘Indomethacin’ and ‘Indapex’
      • 5-MeO-7,N,N-TMT
      • 5-MeO-a,N-DMT, also known as ‘α,N,O-TMS’
      • 4-F-5-MeO-DMT
      • 5-MeS-DMT
      • 5-Me-MiPT, its psychedelic activity is disputed
      • 5-HO-DiPT
      • 2-α-DMT
      • 2-Me-DET
      • 4-Me-αMT
      • 4-Me-αET, also has entactogenic properties
      • 7-Me-αET, also has entactogenic properties
      • 4,5-DHP-AMT, also known as ‘AL-37350A’
      • 4,5-DHP-DMT
      • 4,5-MDO-DMT
      • 4,5-MDO-DiPT
      • 5,6-MDO-DiPT
      • 5,6-MDO-MiPT
      • 5-Fluoro-αMT, also has entactogenic properties
      • 6-Fluoro-αMT
      • 6-Fluoro-DMT
      • N,N-Tetramethylenetryptamine, also known as ‘Pyr-T’
      • 4-HO-pyr-T
      • 5-MeO-pyr-T
      • RU-28306, also known as ‘4,a-Methylene-N,N-DMT’
      • O-4310, also known as ‘6-Fluoro-1-Isopropyl-4-HO-DMT’
      • CP-132,484, also known as ‘4,5-DHP-1-Methyltryptamine’
    • Benzofuran derivatives (technically not tryptamines)
    • Ibogoids (can be classified as complex tryptamines)
    • Ergolines (more specifically lysergamides, which can be classified as complex tryptamines; also contain a phenethylamine backbone)
      • Lysergic acid diethylamide, also known as ‘LSD’ and ‘acid’
      • Lysergic acid amide†, also known as ‘LSA’ and ‘ergine’; the primary active constituent of morning glory and Hawaiian baby woodrose seeds
      • N1-Methyl-lysergic acid diethylamide, also known as ‘MLD-41’
      • N-Acetyl-lysergic acid diethylamide, also known as ‘ALD-52’
      • 1-Propionyl-lysergic acid diethylamide, also known as ‘1P-LSD’; its effects are partially attributed to LSD, to which it is a prodrug via hydrolyzation
      • 6-Allyl-6-nor-lysergic acid diethylamide, also known as ‘AL-LAD’
      • 6-Butyl-6-nor-lysergic acid diethylamide, also known as ‘BU-LAD’
      • 6-Ethyl-6-nor-lysergic acid diethylamide, also known as ‘ETH-LAD’
      • 1-Propionyl-6-Ethyl-6-nor-lysergic acid diethylamide, also known as ‘1P-ETH-LAD’
      • 6-Propyl-6-nor-lysergic acid diethylamide, also known as ‘PRO-LAD’
      • 6-Cyclopropyl-6-nor-lysergic acid diethylamide, also known as ‘CYP-LAD’
      • 6-nor-Lysergic acid diethylamide, also known as ‘PARGY-LAD’
      • Lysergic acid ethylamide, also known as ‘LAE-32’
      • Lysergic acid α-hydroxyethylamide†, also known as ‘LSH’ and ‘LAH’; another active constituent of morning glory seeds; an active constituent of some species of fungi
      • Lysergic acid 2-butyl amide, also known as ‘LSB’
      • Lysergic acid 3-pentyl amide, also known as ‘LSP’
      • Lysergic acid methyl ester, also known as ‘LSME’
      • Lysergic acid 2,4-dimethylazetidide, also known as ‘LSZ’ and ‘LA-SS-Az’
      • Lysergic acid piperidine, also known as ‘LSD-Pip’; its psychedelic activity is disputed
      • N,N-Dimethyl-lysergamide, also known as ‘DAM-57’
      • Methylisopropyllysergamide, also known as ‘MIPLA’
      • N,N-Diallyllysergamide, also known as ‘DAL’
      • N-Pyrrolidyllysergamide, also known as ‘LPD-824’
      • N-Morpholinyllysergamide, also known as ‘LSM-775’
      • 1-methyl-lysergic acid butanolamide, also known as ‘Methysergide’; the active constituent of Sansert and Deseril; a prodrug which has to be metabolized to methylergometrine to become psychoactive
      • Lysergic acid β-propanolamide†, also known as ‘Ergonovine’ and ‘Ergometrine’; another active constituent of morning glory seeds, and an active constituent of ergot fungi
      • Lysergic acid 1-butanolamide†, also known as ‘Methylergonovine’, ‘Methergine’, and ‘Methylergometrine’; another active constituent of morning glory seeds and of ergot fungi
  • Phenethylamines (more specifically alkoxylated phenethylamines)
    • Substituted phenethylamines
      • Mescaline†, the primary active constituent of certain cacti, such as peyote and San Pedro
      • Lophophine†, also known as ‘MMDPEA’; another active constituent of certain cacti, such as peyote and San Pedro; also has entactogenic properties
      • Isomescaline
      • Cyclopropylmescaline
      • Thioisomescaline (2-TIM, 3-TIM, and 4-TIM)
      • 4-Desoxymescaline
      • Jimscaline
      • Escaline
      • Metaescaline
      • Thiometaescaline (3-TME, 4-TME, and 5-TME)
      • Trisescaline
      • Thiotrisescaline (3-T-TRIS and 4-T-TRIS)
      • Symbescaline
      • Asymbescaline
      • Thiosymbescaline (3-TSB and 4-TSB)
      • Phenescaline
      • Allylescaline, also known as ‘AL’
      • Methallylescaline
      • Proscaline
      • Isoproscaline
      • Metaproscaline
      • Thioproscaline
      • Buscaline
      • Thiobuscaline
      • α-ethylmescaline, also known as ‘AEM’
      • Ariadne, also known as ‘α-Et-DOM’, ‘4C-D’, and ‘Dimoxamine’
      • Macromerine
      • MEPEA
      • TOM (2-TOM and 5-TOM)
      • Bis-TOM
      • TOMSO, also known as ‘2-methoxy-4-methyl-5-methylsulfinylamphetamine’
      • TOET (2-TOET and 5-TOET)
      • BOH
      • BOM, also known as ‘β-Methoxy-mescaline’
      • β-D
      • 4-D
      • DME
      • F-2
      • F-22
      • FLEA, also known as ‘MDHMA’
      • MDPH
      • MDMP
      • Propynyl
      • 2C family (2,5-dimethoxy, 4-substituted phenethylamines)
        • βk-2C-B
        • 2C-B
        • 2CB-2EtO
        • 2CB-5EtO
        • 2CB-diEtO
        • 2C-B-FLY
        • 2C-B-BUTTERFLY
        • 2C-C
        • 2C-D
        • 2CD-2EtO
        • 2CD-diEtO
        • 2CD-5EtO
        • 2C-E
        • 2C-EF
        • 2C-F
        • 2C-G (2C-G-1, 2C-G-2, 2C-G-3, 2C-G-4, 2C-G-5, 2C-G-6, and 2C-G-N)
        • 2C-H
        • 2C-I
        • 2CI-2EtO
        • 2C-iP
        • 2C-N
        • 2C-O
        • 2C-O-4
        • 2C-P
        • 2C-SE
        • 2C-T
        • 2CT-5EtO
        • 2C-T-2
        • 2CT-2-2EtO
        • 2CT-2-5EtO
        • 2CT-2-diEtO
        • 2C-T-4 (2C-T-4 and Ψ-2C-T-4)
        • 2CT-4-2EtO
        • 2C-T-7
        • 2CT-7-2EtO
        • 2C-T-8
        • 2C-T-9
        • 2C-T-13
        • 2C-T-15
        • 2C-T-16
        • 2C-T-17
        • 2C-T-19,
        • 2C-T-21
        • 2C-TFM
        • 2C-YN
        • BOB, also known as ‘β-Methoxy-2C-B’
        • BOD, also known as ‘β-Methoxy-2C-D’
        • BOHD, also known as ‘β-Hydroxy-2C-D’
        • HOT-2
        • HOT-7
        • HOT-17
        • Indane derivatives (technically not phenethylamines)
        • Benzocyclobutene derivatives (technically not phenethylamines)
          • 2C-BCB, also known as ‘TCB-2’
        • NBOMe derivatives
          • NBOMe-mescaline
          • 2C-H-NBOMe, also known as ’25H-NBOMe’
          • 2C-C-NBOMe, also known as ’25C-NBOMe’
          • 2CBCB-NBOMe, also known as ‘NBOMe-TCB-2’
          • 2CBFly-NBOMe, also known as ‘Cimbi-31’
          • 2C-B-NBOMe, also known as ’25B-NBOMe’, ‘M25B-NBOMe’, ‘BOM 2-CB’, ‘Cimbi-36’, ‘Nova’, or ‘New Nexus’
          • 2C-I-NBOMe, also known as ’25I-NBOMe’, ‘Cimbi-5’, “Solaris”, or “N-Bomb”
          • 2C-TFM-NBOMe, also known as ’25TFM-NBOMe’
          • 2C-D-NBOMe, also known as ’25D-NBOMe’
          • 2C-G-NBOMe, also known as ’25G-NBOMe’
          • 2C-E-NBOMe, also known as ’25E-NBOMe’
          • 2C-P-NBOMe, also known as ’25P-NBOMe’
          • 2C-iP-NBOMe, also known as ’25iP-NBOMe’
          • 2C-CN-NBOMe, also known as ’25CN-NBOMe’
          • 2C-N-NBOMe, also known as ’25N-NBOMe’
          • 2C-T-NBOMe, also known as ’25T2-NBOMe’
          • 2C-T-4-NBOMe, also known as ’25T4-NBOMe’
          • 2C-T-7-NBOMe, also known as ’25T7-NBOMe’
          • DMBMPP, 2-Benzylpiperidine analogue of 25B-NBOMe
        • NBOH derivatives
          • 2C-C-NBOH, also known as ’25C-NBOH’ and ‘NBOH-2CC’
          • 2C-B-NBOH, also known as ’25B-NBOH’
          • 2C-I-NBOH, also known as ’25I-NBOH’
          • 2C-CN-NBOH, also known as ’25CN-NBOH’ and ‘NBOH-2C-CN’
        • NBMD derivatives
        • NBF derivatives
          • 2C-C-NBF, also known as ’25C-NBF’
          • 2C-B-NBF, also known as ’25B-NBF’
          • 2C-I-NBF, also known as ’25I-NBF’
    • Substituted amphetamines (alpha-methyl-phenethylamines)
      • 3C family (3,5-dimethoxy, 4-substituted amphetamines)
      • DOx family (2,5-dimethoxy, 4-substituted amphetamines)
        • DOAM
        • DOB
        • Meta-DOB
        • Methyl-DOB
        • DOBU
        • DOC
        • DOEF
        • DOET, also known as ‘DOE’
        • DOI
        • DOM, also known as ‘STP’
        • Ψ-DOM
        • DON
        • DOPR
        • DOiPR
        • DOT, also known as ‘Aleph’ (Aleph-2, Aleph-4, Aleph-6, and Aleph-7)
        • Meta-DOT
        • Ortho-DOT
        • DOTFM
      • Phenylcyclopropylamine derivatives (technically not amphetamines)
      • DMMDA
      • DMMDA-2
      • 2,5-dimethoxy-3,4-dimethylamphetamine, also known as ‘Ganesha’; (G-3, G-4, G-5, and G-N)
      • 4-methyl-2,5-dimethoxymethamphetamine, also known as ‘Beatrice’, ‘MDO-D’, and ‘MDOM’
      • 2,N-dimethyl-4,5-methylenedioxyamphetamine, also known as ‘Madam-6’
      • Dimethoxyamphetamine (2,4-DMA, 2,5-DMA, and 3,4-DMA)
      • Trimethoxyamphetamine (TMA-2, TMA-6)
      • Tetramethoxyamphetamine
      • Br-DragonFLY
      • TFMFly
      • 2-Bromo-4,5-methylenedioxyamphetamine
      • 4-Bromo-3,5-dimethoxyamphetamine
      • EEE
      • EEM
      • EME
      • EMM
      • EDMA
      • EIDA
      • Ethyl-J, also known as ‘EBDB’
      • Methyl-J, also known as ‘MDMB’
      • Ethyl-K, also known as ‘EBDP’
      • Methyl-K, also known as ‘MBDP’ and ‘UWA-91’
      • IDNNA
      • Iris
      • MDAI
      • MDMAI
      • MDAT
      • MDMAT
      • MDAL
      • MDBU
      • MDBZ
      • MDDM
      • MDIP
      • MDMEOET
      • MDMEO
      • MDOH, also known as ‘MDH’
      • MDHOET
      • MDPL
      • MDCPM
      • MDPR
      • MEDA
      • MEM
      • Methyl-DMA
      • MMDA, also known as ‘3-methoxy-MDA’ (2T-MMDA-3a and 4T-MMDA-2)
      • MMDA-2
      • 5-Methyl-MDA
      • MEE
      • MME
      • MPM
      • DiFMDA
      • 5-APB
      • 6-APB, also known as ‘Benzofury’
      • 5-APDB
      • 6-APDB
      • 5-MAPB
      • 5-MAPDB
      • 6-MAPDB, its psychedelic activity is disputed
      • 6-MAPB
      • 6-EAPB
      • 5-EAPB
      • Para-Methoxyamphetamine, also known as ‘PMA’ and ‘4-MA’
      • Paramethoxymethamphetamine, also known as ‘PMMA’, ‘Methyl-MA’, and ‘4-MMA’
      • 4-Ethylamphetamine, also known as ‘4-EA’
      • 3-Methoxy-4-methylamphetamine, also known as ‘MMA’
      • 4-Methylmethamphetamine, also known as ‘4-MMA’
      • 4-Methylthioamphetamine, also known as ‘4-MTA’
      • 4-Fluoroamphetamine, also known as ‘4-FA’, ‘PAL-303’, ‘Flux’, ‘Flits’, ‘R2D2’, and ‘Miley’
      • Norfenfluramine, also known as ‘3-TFMA’
      • Para-Iodoamphetamine, also known as ‘PIA’, ‘4-iodoamphetamine’, and ‘4-IA’
      • Para-Chloroamphetamine, also known as ‘PCA’, ‘4-chloroamphetamine’, and ‘4-CA’
  • Benzoxazines (more specifically cyclopropylethynylated benzoxazines)
    • Substituted benzoxazines
      • Efavirenz, the active constituent of Sustiva, Stocrin, and Efavir
  • Substituted methylenedioxy-phenethylamines (MDxx)
    • MDMA, also known as ‘Ecstasy’, ‘Molly’, and ‘Mandy’
    • MDA, also known as ‘Sass’
    • 2,3-MDA, also known as ‘ORTHO-MDA’
    • 5-Methyl-MDA
    • MMDA, also known as ‘3-methoxy-MDA’
    • MDEA, also known as ‘MDE’
    • MBDB
    • MDAL
    • MDBU
    • MDBZ
    • MDDM
    • MDIP
    • MDMEOET
    • MDMEO
    • MDOH, also known as ‘MDH’
    • MDHOET
    • MDPL
    • MDCPM
    • MDPR
    • BDB, also known as ‘MDB’ and ‘J’
    • MMDA-2
    • DiFMDA
    • EIDA
    • Ethyl-K, also known as ‘EBDP’
    • Lophophine†, also known as ‘MMDPEA’; an active constituent of certain cacti, such as peyote and San Pedro
  • Substituted amphetamines (exclusively; most of the substituted methylenedioxy-phenethylamines also overlap this category)
    • EDMA
    • Para-Methoxyamphetamine, also known as ‘PMA’
    • Paramethoxymethamphetamine, also known as ‘PMMA’ and ‘Methyl-MA’
    • 4-Ethylamphetamine, also known as ‘4-EA’
    • 3-Methoxy-4-methylamphetamine, also known as ‘MMA’
    • 4-Methylmethamphetamine, also known as ‘4-MMA’
    • 4-Methylthioamphetamine, also known as ‘4-MTA’
    • 4-Fluoroamphetamine, also known as ‘4-FA’, ‘PAL-303’, ‘Flux’, ‘Flits’, ‘R2D2’, and ‘Miley’
    • Norfenfluramine, also known as ‘3-TFMA’
    • Para-Iodoamphetamine, also known as ‘PIA’, ‘4-iodoamphetamine’, and ‘4-IA’
    • Para-Chloroamphetamine, also known as ‘PCA’, ‘4-chloroamphetamine’, and ‘4-CA’
  • Substituted cathinones
    • Methylone, also known as ‘bk-MDMA’ and ‘MDMC’
    • Ethylone, also known as ‘bk-MDEA’ and ‘MDEC’
    • Eutylone, also known as ‘bk-EBDB’
    • Butylone, also known as ‘bk-MBDB’
    • Pentylone, also known as ‘bk-Methyl-K’ and ‘bk-MBDP’
    • 4-Ethylmethcathinone, also known as ‘4-EMC’
    • 3-Methylmethcathinone, also known as ‘3-MMC’
  • Substituted benzofurans
  • Substituted tetralins
  • Substituted indanes
  • Substituted napthalenes
  • Substituted phenylisobutylamines (alpha-ethyl-phenethylamines)
    • 4-chlorophenylisobutylamine, also known as ‘4-chloro-α-ethylphenethylamine’, ‘4-CAB’, and ‘AEPCA’
    • 4-Methylphenylisobutylamine, also known as ‘4-MAB’
    • Ariadne, also known as ‘α-Et-DOM’, ‘4C-D’, and ‘Dimoxamine’
  • Alpha-substituted (-alkylated) tryptamines
  • Arylcyclohexylamines
    • Phencyclidine, also known as ‘PCP’
    • 3-Methoxyphencyclidine, also known as ‘3-MeO-PCP’
    • 4-Methoxyphencyclidine, also known as ‘4-MeO-PCP’
    • Phencyclamine, also known as ‘PCPr’
    • Rolicyclidine, also known as ‘PCPy’
    • Eticyclidine, also known as ‘PCE’
    • Dieticyclidine, also known as ‘PCDE’
    • Tenocyclidine, also known as ‘TCP’
    • Gacyclidine, also known as ‘GK-11’
    • Ketamine, also known as ‘Special K’
    • Esketamine, also known as ‘(S)-ketamine’
    • Methoxyketamine, also known as ‘2-MeO-ketamine’
    • Methoxetamine, also known as ‘MXE’
    • Methoxmetamine, also known as ‘MXM’
    • Deschloroketamine, also known as ‘DCK’, ‘O-PCM’, ‘2-Oxo-PCM’
    • Tiletamine
    • 3-MeO-PCE
    • O-PCE, also known as ‘2’-Oxo-PCE’
    • 2-TFMDCK, also known as ‘2-Trifluoromethyldeschloroketamine’
    • 3-HO-PCE
    • 3-HO-PCP
    • 3-MeO-PCMo
    • 2-Fluorodeschloroketamine, also known as ‘2-FDCK’, ‘Fluoroketamine’, and ‘2-Fluoroketamine’
    • N-Ethylnorketamine, also known as ‘NENK’ and ‘N-Ethylketamine’
    • Metaphit
    • Fourphit
  • Adamantanes
  • Diarylethylamines
  • Morphinans
    • Dextrallorphan, also known as ‘DXA’
    • Dextromethorphan, also known as ‘DXM’; prodrug to DXO, yields delirious cognitive effects in and of itself (i.e. pre-conversion)
    • Dextrorphan, also known as ‘DXO’; a natural metabolite of DXM (via liver enzyme P450 2D6) responsible for the primary dissociative effects of robo-tripping
    • Oxilorphan
  • Nitrous oxide
  • Neramexane
  • Xenon
  • 2-MDP
  • 8A-PDHQ
  • Aptiganel
  • Chloroform
  • Dexoxadrol
  • Diethyl ether
  • Dizocilpine
  • Etoxadrol
  • Midafotel
  • NEFA
  • Rhynchophylline
  • Noribogaine
  • Perzinfotel
  • Selfotel
  • Phytocannabinoids
    • Δ9-THC†, agonist [1] ; the primary active constituent of cannabis [2]
    • CBD†, negative allosteric modulator, [4] another major active constituent of cannabis
    • CBN†, a minor active constituent of cannabis, also a metabolite of THC and a product of its degradation [ citation needed ]
    • THCV†, a minor active constituent of cannabis
  • Synthetic cannabinoids
    • (C6)-CP 47,497
    • (C9)-CP 47,497
    • 1-Butyl-3-(2-methoxybenzoyl)indole
    • 1-Butyl-3-(4-methoxybenzoyl)indole
    • 1-Pentyl-3-(2-methoxybenzoyl)indole
    • 2-Isopropyl-5-methyl-1-
      (2,6-dihydroxy-4-nonylphenyl)cyclohex-1-ene
    • 4-HTMPIPO
    • 4-Nonylphenylboronic acid
    • 5Br-UR-144
    • 5Cl-APINACA
    • 5Cl-UR-144
    • 5F-3-pyridinoylindole
    • 5F-AB-FUPPYCA
    • 5F-ADB-PINACA
    • 5F-ADBICA
    • 5F-ADB
    • 5F-AMB
    • 5F-APINACA
    • 5F-CUMYL-PINACA
    • 5F-EMB-PINACA
    • 5F-NNE1
    • 5F-PB-22
    • 5F-PCN
    • 5F-PY-PICA
    • 5F-PY-PINACA
    • 5F-SDB-006
    • HHC
    • A-796,260
    • A-834,735
    • A-836,339
    • A-955,840
    • A-40174
    • A-41988
    • A-42574
    • AB-001
    • AB-CHFUPYCA
    • AB-CHMFUPPYCA
    • AB-CHMINACA
    • AB-FUBICA
    • AB-FUBINACA 2-fluorobenzyl isomer
    • AB-FUBINACA
    • AB-PICA
    • AB-PINACA
    • Abnormal cannabidiol
    • ADAMANTYL-THPINACA
    • ADB-CHMINACA
    • ADB-FUBICA
    • ADB-FUBINACA
    • ADB-PINACA
    • ADBICA
    • ADSB-FUB-187
    • Ajulemic acid
    • AM-087
    • AM-411
    • AM-630
    • AM-630
    • AM-679
    • AM-694
    • AM-855
    • AM-883
    • AM-905
    • AM-906
    • AM-919
    • AM-926
    • AM-938
    • AM-1220
    • AM-1221
    • AM-1235
    • AM-1241
    • AM-1248
    • AM-1346
    • AM-1387
    • AM-1714
    • AM-2201
    • AM-2232
    • AM-2233
    • AM-2389
    • AM-4030
    • AM-4113
    • AM-6527
    • AM-6545
    • AM-251
    • AM-281
    • AM-404
    • AMB-CHMINACA
    • AMB-FUBINACA
    • AMG-1
    • AMG-3
    • AMG-36
    • AMG-41
    • APICA
    • APINACA, also known as ‘AKB48’
    • APP-FUBINACA
    • Arachidonoyl serotonin
    • ACEA
    • ACPA
    • Arvanil
    • AZ-11713908
    • BAY 38-7271
    • BAY 59-3074
    • BIM-018
    • Biochanin A
    • BML-190
    • Nabidrox (Canbisol)
    • Cannabicyclohexanol
    • Cannabipiperidiethanone
    • CAY-10401
    • CAY-10429
    • CAY-10508
    • CB-13
    • CB-25
    • CB-52
    • CB-86
    • CB-86
    • CBS-0550
    • CP 47,497
    • CP 55,244
    • CP 55,940
    • CUMYL-5F-PICA
    • CUMYL-BICA
    • CUMYL-PICA
    • CUMYL-PINACA
    • CUMYL-THPINACA
    • Dexanabinol, also known as ‘HU-211’
    • Dimethylheptylpyran, also known as ‘DMHP’
    • Drinabant, also known as ‘AVE1625’
    • Dronabinol
    • EAM-2201
    • EMB-FUBINACA
    • FAB-144
    • FDU-NNE1
    • FDU-PB-22
    • FUB-144
    • FUB-APINACA
    • FUB-JWH-018
    • FUB-PB-22
    • FUBIMINA
    • Genistein
    • GW-405,833, also known as ‘L-768,242’
    • GW-842,166X
    • Hemopressin
    • HU-210
    • HU-243
    • HU-308
    • HU-320
    • HU-331
    • HU-336
    • HU-345
    • HU-910
    • Ibipinabant, also known as ‘SLV319’
    • IDFP
    • JNJ 1661010
    • JTE-907
    • JTE 7-31
    • JWH-007
    • JWH-015
    • JWH-018
    • JWH-019
    • JWH-030
    • JWH-051
    • JWH-073
    • JWH-081
    • JWH-098
    • JWH-116
    • JWH-122
    • JWH-133
    • JWH-139
    • JWH-147
    • JWH-149
    • JWH-161
    • JWH-164
    • JWH-167
    • JWH-175
    • JWH-176
    • JWH-182
    • JWH-184
    • JWH-185
    • JWH-192
    • JWH-193
    • JWH-194
    • JWH-195
    • JWH-196
    • JWH-197
    • JWH-198
    • JWH-199
    • JWH-200
    • JWH-203
    • JWH-210
    • JWH-229
    • JWH-249
    • JWH-250
    • JWH-251
    • JWH-302
    • JWH-307
    • JWH-359
    • JWH-369
    • JWH-370
    • JWH-398
    • JWH-424
    • JZL184
    • JZL195
    • Kaempferol
    • KM-233
    • L-759,633
    • L-759,656
    • LASSBio-881
    • LBP-1
    • Leelamine
    • Levonantradol, also known as ‘CP 50,5561’
    • LH-21
    • LY-320,135
    • LY-2183240
    • MAM-2201
    • MDA-7
    • MDA-19
    • MDA-77
    • MDMB-CHMICA
    • MDMB-CHMINACA
    • MDMB-FUBINACA
    • Menabitan
    • MEPIRAPIM
    • Methanandamide, also known as ‘AM-356’
    • MJ-15
    • MK-9470
    • MMB-2201
    • MN-18
    • MN-25, also known as ‘UR-12’
    • Nabazenil
    • Nabilone
    • Nabitan
    • Naboctate
    • NESS-0327
    • NESS-040C5
    • NIDA-41020
    • NM-2201
    • NMP-7
    • NNE1
    • Nonabine
    • O-224
    • O-581
    • O-585
    • O-606
    • O-689
    • O-774
    • O-806
    • O-823
    • O-889
    • O-1057
    • O-1125
    • O-1184
    • O-1191
    • O-1238
    • O-1248
    • O-1269
    • O-1270
    • O-1376
    • O-1399
    • O-1422
    • O-1601
    • O-1602
    • O-1624
    • O-1656
    • O-1657
    • O-1660
    • O-1812
    • O-1860
    • O-1861
    • O-1871
    • O-1918
    • O-2048
    • O-2050
    • O-2093
    • O-2113
    • O-2220
    • O-2365
    • O-2372
    • O-2373
    • O-2383
    • O-2426
    • O-2484
    • O-2545
    • O-2654
    • O-2694
    • O-2715
    • O-2716
    • O-3223
    • O-3226
    • Oleoylethanolamide, also known as ‘OEA’
    • Olvanil
    • Org 27569
    • Org 27759
    • Org 28312
    • Org 28611
    • Org 29647
    • Otenabant, also known as ‘CP-945,598’
    • Palmitoylethanolamide, also known as ‘PEA’
    • Parahexyl
    • PF-03550096
    • PF-04457845
    • PF-622
    • PF-750
    • PF-3845
    • PF-514273
    • PHOP
    • PipISB
    • Pirnabine
    • Pravadoline
    • Pregnenolone
    • PSB-SB-487
    • PSB-SB-1202
    • PTI-1
    • PTI-2
    • PX-1
    • PX-2
    • PX-3
    • QUCHIC, also known as ‘BB-22’
    • QUPIC, also known as ‘PB-22’
    • RCS-4
    • RCS-8
    • Rimonabant, also known as ‘SR141716’
    • Rosonabant, also known as ‘E-6776’
    • RTI-371
    • S-444,823
    • SDB-006
    • SER-601
    • SPA-229
    • SR-144,528
    • STS-135
    • Surinabant, also known as ‘SR147778’
    • Taranabant, also known as ‘MK-0364’
    • Tedalinab
    • THC-O-acetate
    • THC-O-phosphate
    • THJ-018
    • THJ-2201
    • Tinabinol
    • TM-38837
    • UR-144
    • URB-447
    • URB-447
    • URB-597
    • URB-602
    • URB-754
    • VCHSR
    • VDM-11
    • VSN-16
    • WIN 54,461
    • WIN 55,212-2
    • WIN 56,098
    • XLR-11
    • Yangonin

Other

  • Harmaline†, harmala alkaloids†, and other beta-carbolines, active constituents of ayahuasca; powerful MAOIs (can be classified as indoles)
  • Salvinorin A†, an opioid (κ-opioid receptor agonist), the active constituent of Salvia divinorum sage
  • Salvinorin B methoxymethyl ether†, a semi-synthetic analogue of the natural product salvinorin A with longer duration and increased affinity and potency at the κ-opioid receptor
  • Salvinorin B ethoxymethyl ether†, a semi-synthetic analogue of the natural product salvinorin A with longer duration and increased affinity and potency at the κ-opioid receptor
  • Piperazines, such as pFPP and TFMPP, usually classified as stimulants
  • Myristicin† and elemicin†, the active constituents of nutmeg
  • Cryogenine (Vertine)†, the active constituent of certain Heimia species
  • Atropine†, scopolamine†, and hyoscyamine†, the active constituents of certain Solanaceae species
  • Ibotenic acid† and muscimol†, the active constituents of Amanita muscaria mushrooms

See also

Related Research Articles

Psychedelic drug serotonin receptor agonist temporarily altering states of consciousness

Psychedelics are a subcategory of psychotropics, which includes all psychoactive substances. Psychedelics are a hallucinogenic class of psychoactive drug whose primary action is to trigger psychedelic experiences via serotonin receptor agonism, causing specific psychological, visual and auditory changes, and altered state of consciousness. Major psychedelic drugs include mescaline, LSD, psilocybin, and DMT.

The Controlled Drugs and Substances Act is Canada’s federal drug control statute. Passed in 1996 under Prime Minister Jean Chrétien’s government, it repeals the Narcotic Control Act and Parts III and IV of the Food and Drugs Act, and establishes eight Schedules of controlled substances and two Classes of precursors. It provides that “The Governor in Council may, by order, amend any of Schedules I to VIII by adding to them or deleting from them any item or portion of an item, where the Governor in Council deems the amendment to be necessary in the public interest.”

4-HO-MiPT chemical compound

4-HO-MiPT is a synthetic substituted aromatic compound and a lesser-known psychedelic tryptamine. It is thought to be a serotonergic psychedelic, similar to magic mushrooms, LSD and mescaline. Its molecular structure and pharmacological effects somewhat resemble those of the tryptamine psilocin, which is the primary psychoactive chemical in magic mushrooms.

Lysergic acid hydroxyethylamide chemical compound

D-Lysergic acid α-hydroxyethylamide, also known as D-lysergic acid methyl carbinolamide, is an alkaloid of the ergoline family, believed to be present in small amounts in various species in the Convolvulaceae (LSA), as well as some species of fungi.

Serotonin receptor agonist Endogenous compounds and drugs that bind to and activate serotonin receptors. Many serotonin receptor agonists are used as antidepressants; anxiolytics; and in the treatment of migraine disorders

A serotonin receptor agonist is an agonist of one or more serotonin receptors. They activate serotonin receptors in a manner similar to that of serotonin, a neurotransmitter and hormone and the endogenous ligand of the serotonin receptors.

25I-NBOH chemical compound

25I-NBOH is a derivative of the phenethylamine-derived hallucinogen 2C-I that was discovered in 2006 by a team at Purdue University.

25I-NBOMe chemical compound

25I-NBOMe is a synthetic hallucinogen that is used in biochemistry research for mapping the brain’s usage of the type 2A serotonin receptor; it is also sometimes used for recreational purposes. A derivative of the substituted phenethylamine 2C-I family, it is the most well-known member of the 25-NB family. It was discovered in 2003 by chemist Ralf Heim at the Free University of Berlin, who published his findings in his PhD dissertation. The compound was subsequently investigated by a team at Purdue University led by David Nichols.

2CBCB-NBOMe chemical compound

2CBCB-NBOMe (NBOMe-TCB-2) is a compound indirectly derived from the phenethylamine series of hallucinogens, which was discovered in 2007 at Purdue University as part of the ongoing research program of the team led by David Nichols focusing on the mapping of the specific amino acid residues responsible for ligand binding to the 5HT2A receptor. 2CBCB-NBOMe acts as a potent and selective agonist for the 5-HT2A and 5-HT2C receptors, with a Ki of 0.27nM at the human 5-HT2A receptor, a similar potency to other agonists such as TCB-2, NBOMe-2C-I and Bromo-DragonFLY.

2CBFly-NBOMe chemical compound

2CBFly-NBOMe is a compound indirectly derived from the phenethylamine hallucinogen 2C-B, and related to benzodifurans like 2C-B-FLY and N-benzylphenethylamines like 25I-NBOMe. It was discovered in 2002, and further researched by Ralf Heim at the Free University of Berlin, and subsequently investigated in more detail by a team at Purdue University led by David E. Nichols. It acts as a potent partial agonist for the 5HT2A serotonin receptor subtype.

2CB-Ind chemical compound

2CB-Ind is a conformationally-restricted derivative of the phenethylamine hallucinogen 2C-B, discovered in 1974 by Alexander Shulgin. It acts as a moderately potent and selective agonist for the 5-HT2A and 5-HT2C receptors, but unlike the corresponding benzocyclobutene derivative TCB-2 which is considerably more potent than the parent compound 2C-B, 2CB-Ind is several times weaker, with racemic 2CB-Ind having a Ki of 47nM at the human 5-HT2A receptor, only slightly more potent than the mescaline analogue (R)-jimscaline.

25TFM-NBOMe chemical compound

25TFM-NBOMe is a derivative of the phenethylamine hallucinogen 2C-TFM, discovered in 2004 by Ralf Heim at the Free University of Berlin. It acts as a potent partial agonist for the 5HT2A receptor, though its relative potency is disputed, with some studies finding it to be of lower potency than 25I-NBOMe, while others show it to be of similar or higher potency, possibly because of differences in the assay used. 2C-TFM-NB2OMe can be taken to produce psychedelic effects similar to 2C-I-NB2OMe and 2C-D-NB2OMe.

25C-NBOMe chemical compound

25C-NBOMe is a psychedelic drug and derivative of the psychedelic phenethylamine 2C-C. 25C-NBOMe appeared on online vendor sites in 2010 but was not reported in the literature until 2011. It acts as a potent agonist for the 5HT2A receptor, and has been studied in its 11C radiolabelled form as a potential ligand for mapping the distribution of 5-HT2A receptors in the brain, using positron emission tomography (PET).

25C-NBOH chemical compound

25-C-NBOH is a derivative of the phenethylamine derived hallucinogen 2C-C which has been sold as a designer drug. It has similar serotonin receptor affinity to the better-known compound 25C-NBOMe.

25CN-NBOMe chemical compound

25CN-NBOMe is a derivative of the phenethylamine 2C-CN. It acts in a similar manner to related compounds such as 25I-NBOMe, which are potent agonists at the 5HT2A receptor.

FUBIMINA

FUBIMINA is a synthetic cannabinoid that is the benzimidazole analog of AM-2201 and has been used as an active ingredient in synthetic cannabis products. It was first identified in Japan in 2013, alongside MEPIRAPIM.

Mepirapim

MEPIRAPIM is a indole-based cannabinoid which differs from JWH-018 by having a 4-methylpiperazine group in place of the naphthyl group and has been used as an active ingredient in synthetic cannabis products. It was first identified in Japan in 2013, alongside FUBIMINA.

25B-NBOH

25B-NBOH is a derivative of the phenethylamine derived hallucinogen 2C-B which has been sold as a designer drug. It acts as a potent serotonin receptor agonist with similar affinity to the better-known compound 25B-NBOMe at 5-HT2A and 5-HT2C receptors with pKis values of 8.3 and 9.4, respectively.

25G-NBOMe chemical compound

25G-NBOMe (NBOMe-2C-G) is a derivative of the phenethylamine hallucinogen 2C-G, which acts as a highly potent partial agonist for the human 5-HT2A receptor.

25H-NBOMe chemical compound

25H-NBOMe (NBOMe-2C-H) is a derivative of the phenethylamine hallucinogen 2C-H, which acts as a highly potent partial agonist for the human 5-HT2A receptor.

References

  1. ↑ Pertwee, R G (April 2006). “The pharmacology of cannabinoid receptors and their ligands: an overview”. International Journal of Obesity. 30 (S1): S13–S18. doi: 10.1038/sj.ijo.0803272 . ISSN   0307-0565. PMID   16570099.
  2. Cannabis and cannabinoids : pharmacology, toxicology, and therapeutic potential. Grotenhermen, Franjo., Russo, Ethan. New York: Haworth Integrative Healing Press. 2002. ISBN   9781136614941. OCLC   606854125.CS1 maint: others (link)
  3. ↑ Huestis, M. A. (2005), “Pharmacokinetics and Metabolism of the Plant Cannabinoids, Δ9-Tetrahydrocannibinol, Cannabidiol and Cannabinol”, in Pertwee, Roger G. (ed.), Cannabinoids, Handbook of Experimental Pharmacology, 168, Springer-Verlag, pp. 657–690, doi:10.1007/3-540-26573-2_23, ISBN   9783540225652
  4. ↑ Laprairie, R B; Bagher, A M; Kelly, M E M; Denovan‐Wright, E M (October 2015). “Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor”. British Journal of Pharmacology. 172 (20): 4790–4805. doi:10.1111/bph.13250. ISSN   0007-1188. PMC   4621983 . PMID   26218440.

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