Instructor, Leslie Winkle 30 Episodes (2007-2016)
Barry Kripke, Kripke 21 Episodes (2009-2018)
Dr. Eric Gablehauser, Gablehauser 19 Episodes (2007-2008)
Ellen, Emily, Emily Sweeney 15 Episodes (2014-2017)
Beverly, Dr. Beverly Hofstadter 13 Episodes (2009-2019)
Dr. Koothrappali, Dr. V.M. Koothrappali 12 Episodes (2007-2019)
Pres. Seibert, Presdient Siebert, President Siebert 8 Episodes (2011-2019)
Mrs. Koothrappali 8 Episodes (2007-2012)
Mrs. Wolowitz, Mrs.Wolowitz 7 Episodes (2007-2014)
Arthur Jeffries, Prof. Proton, Prof. Proton/Arthur, Professor Proton 6 Episodes (2013-2018)
Janine Davis, Mrs. Davis 5 Episodes (2013-2017)
Halley, Halley (O.S.) 5 Episodes (2016-2019)
Guard, Police Officer, Security Guard 3 Episodes (2010-2016)
Dr. Ramona Nowitzki, Ramona 3 Episodes (2008-2017)
Cleaning Lady, Maria 3 Episodes (2008-2015)
Analeigh, Vanessa 2 Episodes (2008-2015)
Dr. Elizabeth Plimpton 1 Episode (2010)
Dr. Catherine Millstone 1 Episode (2009)
Security Guard No. 2 1 Episode (2015)
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